The main purpose of all vaccines and consequently vaccination is to administer an optimum and safe amount of antigen to elicit immune response in the bird. Vaccination does not give guarantee that birds are protected. There are a number of factors which may furnish the success of a vaccine. It is a worth remembering that antigens or vaccine or vaccination itself does not produce immunity rather it is the bird’s immune system in general and immune cells in particular that provoke the immune response and present the antigen to T lymphocytes and by macrophages and from there it is expressed to b lymphocyte where the immune response initiated in items of antibodies. These antibodies are identical to the antigen of vaccine. The successful vaccination comes up in terms of higher and stronger immunity. On most of the occasions we get proper protection with vaccination but immunity breakdown is usually not known. The current topic highlighted the factors which will come up in term of
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