Drug discovery and design is a complex process that requires collaboration between various fields, including chemistry, biology, pharmacology, and more. Within this pipeline, biochemists play a critical role in understanding the biochemical mechanisms that underlie diseases and drug targets, designing and optimising drug candidates, and ensuring their safety and efficacy. Starting at the earliest stage of drug discovery, biochemists work to identify and validate potential drug targets by studying the structure and function of proteins, enzymes, and other biological molecules. They may use a variety of techniques; including X-ray crystallography, NMR spectroscopy, and mass spectrometry, to determine the 3D structure of these molecules and understand how they interact with other proteins or ligands in the body. Once a drug target has been identified, biochemists help design and optimise drug candidates that can selectively bind to and modulate the activity of the target molecule. T
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