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Research Activities to Bring New Wound Debridement Options for Patients

Surge in incidence of chronic wounds such as diabetic foot ulcers, pressure ulcers, radiation wounds, infectious wounds, arterial ulcers, and acute wound including burn and trauma drives the demand for wound debridement. Improving the quality of lives of patients suffering chronic wounds is a major aim for researchers and companies operating in the wound debridement sector and wound care space. Research institutes and researchers from universities across the world are conducting trials and revealing results. They researched the effectiveness of wound debridement for complex foot infections along with venous leg ulcers (VLUs). Researchers from different organizations and institutes from the U.S. and the U.K. are on the forefront of developing new wound debridement options for patients suffering from chronic wounds. They aim to develop innovative solutions and launch products that would become preferred options for patients and enhance the quality of lives. Clinical trials have been conducted and conclusions for various phases of trials have been drawn. The further steps will help these companies and organizations in gaining approval for their products. Innovative products and options will become available in the coming years. According to the report published by Allied Market Research, the global wound debridement market is estimated to reach $5.67 billion by 2030. Following are some of the activities taking place across the world.

Researchers from the U.K. conducted a research in which they treated complex foot infections with surgical debridement along with antibiotics containing calcium sulfate. These infections contain soft and bone tissues in patients suffering from peripheral arterial disease (PAD) and diabetes. The courses of systematic antibiotics led to high economic costs, side effects of drugs, and antimicrobial resistance.

In the new research, researchers determined the effectiveness of surgical debridement along with antibiotics containing calcium sulfate on resolving foot infections and healing of wounds. In a research conducted on 137 patients, they measured outcomes regarding resolution of infection, time required for healing, and duration for which postoperative antibiotics were used. The outcomes showed that nearly 88% of infections were resolved. For 22 patients, postoperative systemic antibiotics were not needed. The average healing time required was nearly 11.3 weeks. The healing time surged considerably for patients suffering from PAD and diabetes. In conclusion, researchers stated that surgical debridement and antibiotics containing calcium sulfate are effective and safe for management of complex foot infections.

Biopharmaceutical companies are also conducting trials for testing effectiveness of debridement for various conditions. MediWound Ltd., a biopharmaceutical company focused on development of biotherapeutic solutions for tissue repair and regeneration, concluded the phase two of the clinical study of EscharEx for venous leg ulcers (VLUs) debridement. The company highlighted that the study reached the primary endpoint. It showed the high degree of statistical significance and concluded that patients treated with EscharEx had a considerably high incidence of entire debridement. Moreover, the effectiveness of EscharEx was statistically higher even when compared to gel vehicle. Researchers also observed the favorable reduction in wound area and pain as compared to application of gel vehicle.

Commenting on the end of phase two, Sharon Malka, the Chief Executive Officer of MediWound, stated that this result shows that the potential benefits of EscharEx on patient lives in terms of clinical and physical outcomes. EscharEx is only a step away from becoming the best-in-class and non-surgical debridement choice for patients undergoing chronic wounds. The company would enter the billion-dollar market of chronic wound care and gain a major market share with implementation of EscharEx. It will advance toward the phase three of the EscharEx clinical program. Such research activities and clinical trials will bring a new option for wound debridement and transform the wound healing process.  

Author Bio

Pratik Kirve

Email: pratik.kirve@alliedmarketresearch.net

LinkedIn: https://www.linkedin.com/in/pratik-kirve-8213b284/

Pratik Kirve is a writer, blogger, and sport enthusiast. He holds a bachelor’s degree in Electronics and Telecommunication Engineering, and is currently working as a Team Lead - Content Writing at Allied Market Research. He has an avid interest in writing news articles across different verticals. When he is not following updates and trends, he spends his time reading, writing poetry, and playing football.

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